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NAD+ (1000mg)

NAD+ (1000mg)

For Research Use Only •

Original price was: $150.00.Current price is: $97.00.

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in all living cells, essential for metabolic processes and cellular function. It acts as a mediator of redox reactions, alternating between its oxidized (NAD+) and reduced (NADH) forms to facilitate electron transfer, crucial for energy production and sustaining life. Involved in over 500 enzymatic reactions, NAD+ is central to maintaining cellular homeostasis. Research shows that NAD+ may be beneficial in improving muscle function, protecting cells of the nervous system, and generally reducing the effects of aging.

Beyond energy metabolism, NAD+ supports DNA repair and gene regulation through enzymes like sirtuins and PARPs. Sirtuins use NAD+ to regulate cellular functions such as DNA repair, gene expression, and aging, while PARPs utilize it to repair DNA damage and maintain genomic stability. These roles underscore NAD+’s importance in cellular integrity and combating aging.

  • 1 x 10ml sterile multi-dose vial
  • Active ingredient: NAD⁺ (Nicotinamide Adenine Dinucleotide) at 100mg/ml
  • Clear, aqueous solution
  • Preserved with bacteriostatic saline
  • Packaged in tamper-evident USP-grade vial
  • Designed for intramuscular injection only

NAD⁺ is a vital coenzyme found in all living cells, playing a central role in mitochondrial function, energy metabolism, DNA repair, and cellular signaling. It is an essential molecule in redox reactions, particularly in converting nutrients into cellular energy (ATP) via the Krebs cycle and oxidative phosphorylation.

NAD⁺ levels naturally decline with age, stress, toxin exposure, and chronic illness — contributing to mitochondrial dysfunction, fatigue, cognitive decline, and metabolic syndromes. Intramuscular NAD⁺ supplementation may help restore these levels, promoting systemic vitality and neuroprotection.

NAD⁺ functions as a critical redox coenzyme, alternating between NAD⁺ and NADH to shuttle electrons during cellular respiration. It is essential for ATP production, cellular repair, and signaling.

Key pathways affected by NAD⁺ include:

  • Mitochondrial function: Boosts oxidative phosphorylation and cellular energy
  • Sirtuin activation: Supports anti-aging gene expression and DNA repair
  • PARP activity: Promotes DNA damage response and genomic stability
  • Neurotransmitter synthesis: Assists in dopamine, serotonin, and noradrenaline metabolism
  • Detoxification: Assists liver in converting reactive oxygen species and toxins

By replenishing NAD⁺ levels, the body may restore metabolic efficiency, immune balance, and neurological resilience.

NAD⁺ is typically well tolerated when administered properly, though injection technique and dosage are key to minimizing discomfort.

Potential side effects include:

  • Localized muscle soreness or cramping (due to IM injection)
  • Mild headache or flushing
  • Fatigue or lethargy (typically short-lived)
  • Nausea or lightheadedness during/after injection if pushed too rapidly

These effects are usually transient and may be reduced by slower administration and dose titration.

Potential Benefits:
  • Increased energy production and reduced fatigue
  • Enhanced focus, mood, and cognitive performance
  • Improved metabolic function and insulin sensitivity
  • Cellular anti-aging and DNA repair support
  • Detoxification and neuroprotective effects
  • May aid in addiction recovery and withdrawal management
⚠️ Possible Side Effects:
  • Injection site pain or muscle soreness
  • Headache or flushing
  • Temporary fatigue or lightheadedness
  • Nausea if administered too quickly
  • Rare: anxiety or restlessness in very sensitive individuals
  • Not recommended for individuals with known hypersensitivity to NAD⁺ or its precursors
  • Use caution in individuals with hypotension, as NAD⁺ may mildly lower blood pressure
  • Should be used carefully in those with severe hepatic or renal impairment
  • NAD⁺ may interact with certain cancer therapies that rely on NAD⁺ depletion mechanisms

Always inject slowly and monitor for any signs of systemic discomfort, especially at higher doses.

There are no known severe drug interactions. However, consider the following:

  • May enhance mitochondrial function, affecting drug metabolism
  • Synergistic with sirtuin activators like resveratrol or pterostilbene
  • May interact with chemotherapy agents targeting NAD⁺-dependent enzymes
  • Compatible with:
    • Vitamin B complex
    • CoQ10
    • Glutathione
    • L-carnitine and other mitochondrial support compounds

There is limited human safety data on NAD⁺ injections in pregnant or breastfeeding individuals. While NAD⁺ is a naturally occurring molecule, use during pregnancy or lactation is not currently recommended due to lack of conclusive data.

NAD⁺ injections are not approved for pediatric use. While NAD⁺ is vital to metabolism in all age groups, supplementation should be reserved for adults unless prescribed by a pediatric specialist under clinical supervision.

NAD⁺ is not FDA-approved as a pharmaceutical drug for injectable use. It is available through compounding pharmacies and used in clinical wellness, addiction recovery, anti-aging, and functional medicine practices. FDA-approved uses of NAD precursors (e.g., niacinamide) exist, but injectable NAD⁺ is considered investigational.

  1. Rajman L, et al. (2018). “NAD⁺ as a metabolic and signaling molecule in aging and disease.” Cell Metabolism.
  2. Trammell SA, et al. (2016). “Pharmacokinetics of NAD⁺ precursors in humans.” Nature Communications.
  3. Ying W. (2008). “NAD⁺ and NADH in cellular functions and neurodegeneration.” Antioxidants & Redox Signaling.
  4. Grant R, et al. (2019). “NAD⁺ replenishment improves mitochondrial function in patients with chronic fatigue.” Mitochondrion.
  5. Liu L, et al. (2017). “NAD⁺ metabolism and its roles in cellular repair.” Annual Review of Biochemistry.

Product Usage
 This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.Comprehensive Legal DisclaimerCoreTrustLabs (“the Company”) operates solely as an independent intermediary and online trading platform connecting qualified laboratories, research institutions, and licensed distributors with verified suppliers of laboratory-grade research materials, including but not limited to peptides, amino acid derivatives, and other chemical reagents.The Company does not manufacture, compound, import, export, store, handle, or physically distribute any substances listed or referenced on this website or in any communications. 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