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TB-500 (Thymosin Beta-4) is a 43 amino acid peptide sequence. In animal models, Thymosin Beta-4 has been shown to improve blood vessel growth, regulate wound healing, decrease inflammation, and reduce oxidative damage in the heart and central nervous system. Thymosin-beta-4 has a role in protection, tissue repair, regeneration and remodeling of injured or damaged tissues. It is also of active interest in anti-aging research.
TB-500 is commonly administered via subcutaneous injection, and dosing is typically escalated gradually for optimal effect. A typical protocol begins with a loading phase, followed by a maintenance phase.
During the loading phase, a common approach is to start with 2 mg (1 ml) administered twice weekly for the first 4–6 weeks. Depending on the individual's recovery response and goals, this phase may be shortened or extended slightly.
After this, a maintenance dose of 2 mg once weekly (1 ml per injection) is often used to support ongoing tissue repair, mobility, or recovery. Some protocols reduce the dose to 1 mg weekly (0.5 ml) if goals have shifted toward general wellness or long-term joint support.
The peptide is best administered subcutaneously into areas of subcutaneous fat (such as the abdomen or thigh), and injection sites should be rotated regularly to avoid irritation. For injury recovery, some clinicians prefer to inject near the site of damage, though this should be done with caution and proper sterile technique.
A 10ml vial of TB-500 at 2mg/ml provides a total of 20mg of peptide, allowing for 10 full 2mg doses or 20 x 1mg doses, depending on the protocol selected.
Thymosin Beta-4 (TB-500) is a synthetic peptide analog of a naturally occurring protein found in nearly all human and animal cells. It plays a vital role in cell migration, angiogenesis, inflammation modulation, and tissue regeneration.
TB-500 has been studied for its regenerative potential in soft tissue injuries, post-surgical recovery, inflammation reduction, and cardiovascular repair. It mimics a portion of the larger thymosin beta-4 molecule, specifically the active sequence responsible for its wound healing and cytoprotective effects.
Its ability to promote actin polymerization, increase blood vessel formation, and reduce fibrosis makes it an attractive option in physical rehabilitation, joint health, and overall recovery optimization.
TB-500’s primary function lies in its regulation of actin, a vital component of cellular structure and mobility. By increasing the availability of G-actin, TB-500 accelerates cell migration, crucial for tissue repair and wound healing.
Additional mechanisms include:
Angiogenesis promotion through upregulation of VEGF (vascular endothelial growth factor)
Anti-inflammatory activity via downregulation of NF-kB and other cytokines
Collagen remodeling and support of extracellular matrix stability
Enhanced keratinocyte and endothelial cell migration, aiding both soft tissue and epithelial recovery
TB-500 also exhibits protective effects on the heart, cornea, tendons, and nervous system, making it a broad-spectrum regenerative peptide.
There is currently no safety data available regarding the use of TB-500 in pregnant or breastfeeding women. Animal studies have not established teratogenicity, but due to a lack of definitive data, use during pregnancy and lactation is not recommended.
TB-500 has not been studied in pediatric populations. Due to its effect on cellular growth, tissue regeneration, and angiogenesis, it is not recommended for use in children unless prescribed by a qualified specialist under closely monitored conditions.
Thymosin Beta-4 (TB-500) is not approved by the FDA for any specific medical indication. It is currently available for research and compounding pharmacy use, based on its extensive preclinical study in tissue regeneration, cardiovascular healing, and post-injury recovery.
